تعیین اثر میزوپروستول خوراکی برای درمان سقط ناقص خودبه‌خودی در 3 ماهه اول بارداری

The object of the present study was to evaluate oral misoprostol effect on the treatment of spontaneous first trimester incomplete abortion. An experimental study was performed on 97 women who were admitted to the hospital with the diagnosis of spontaneous incomplete abortion(diagnosed clinically(22.7%) or sonographically(77.3%)). At first, 600μg misoprostol (Cytotec in the form of 200 μg tablet) and then, if needed, two doses of 400μg, was prescribed, every two hours (total 1400μg). Drug effect was defined as complete evacuation of uterus without needing curetage. The next day after misoprostol prescription sonography was performed and with confirmation of empty uterus and completion of abortion, the patients were discharged. All of the patients were checked up at least once in the next three weeks and evaluated for probable complications.Of 97 patients, 69(71.1%) did not need surgical evacuation(8(11.59%) with two doses and 61 with three doses). Side effects of misoprostol were minimal and were tolerated by the patients well. Misoprostol use is a simple, safe and effective method for completion of incomplete abortion with no expense and surgical evacuation complications.